工作學(xué)習(xí)經(jīng)歷： PROFESSIONAL EXPERIENCE
1997年進(jìn)入日本國立九州工業(yè)大學(xué)大學(xué)院，師從于緩控釋給藥（ Drug Delivery System, DDS）領(lǐng)域知名的KAKUJI TOJO教授（AAPS創(chuàng)始人會(huì)員，Eur.J. Pharma.&Biopharma.編委）學(xué)習(xí)，2003 年取得博士學(xué)位，2003 年4月受聘大連理工大學(xué)副教授，2010年任大連理工大學(xué)教授。現(xiàn)任大連理工大學(xué)制藥科學(xué)與技術(shù)學(xué)院教授博士生導(dǎo)師，現(xiàn)代給藥系統(tǒng)與功能性材料學(xué)術(shù)帶頭人。
In 1997, Enrolled in Kyushu Institute of Technology in Japan, learned the technology of drug delivery. Obtained doctor degree in 2003. Worked in Dalian University of Technology since 2003, engaged in teaching and research work.Now, Hold Professor in Pharmacy Science and Technology Insititute, DLUT,Doctoral supervisor, Director in Modern DDS & Functional Material Group.
主要學(xué)術(shù)兼職： PLURALITY
1.教育部科研基金和科技獎(jiǎng)勵(lì)評(píng)審專家
2.國家食品藥品監(jiān)督管理總局 新藥評(píng)審和化妝品審評(píng)專家；
3.國家重大新藥創(chuàng)制項(xiàng)目審評(píng)（驗(yàn)收）專家;
4.世界中醫(yī)藥學(xué)會(huì)聯(lián)合會(huì)新型給藥技術(shù)專業(yè)委員會(huì)常務(wù)理事;
5.遼寧省保健品化妝品專家委員會(huì)委員；
6.大連市優(yōu)秀專家；
7.中文核心期刊《中國實(shí)驗(yàn)方劑學(xué)雜志》和《中國醫(yī)藥技術(shù)經(jīng)濟(jì)與管理》編委；《International Journal of Pharmaceutical Science》，《Molecule Pharmaceutics》等英文雜志審稿人
1.Expert for Research Fund and technology award evaluation of Ministry of Education China;
2.Expert for the New Drug Assessment Centre of State of Food and Drug Administration;
3.Expert for Cosmetic Assessment Centre of State of Food and Drug Administration;
4.Director of the World Association of Traditional Chinese Medicine Association the Professional
5.Committee on the New Drug Administration Technology;
6.Committeeman in Chinese Medicine Research Association Professional Committee of TCM
7.Outstanding Expert of Dalian City
8.Editor for Chinese Journal of Pharmaceutical Technology Economics & Management;
9.Editor for China Journal of Experimental Traditional Medical Formulae.
10.Reader for 《 International Journal of Pharmaceutical Science》 ,《 Molecule Pharmaceutics》 and etc.
研究領(lǐng)域和方向: SPECIALITY AND RESEARCH FIELD
研究領(lǐng)域：現(xiàn)代給藥技術(shù)與功能性藥用材料
研究方向： 1、功能性材料及緩控釋給藥系統(tǒng)的研究
—壓敏膠載藥基質(zhì)設(shè)計(jì)與合成研究；
—原位凝膠給藥材料
2、 經(jīng)皮給藥計(jì)算機(jī)模擬與 PK/PD 相關(guān)性研究
— 經(jīng)皮給藥系統(tǒng)的設(shè)計(jì)與優(yōu)化；
— 藥物（有效成分） 跨膜滲透動(dòng)力學(xué)研究；
3、生物大分子經(jīng)皮/跨膜給藥系統(tǒng)研究
— 生物大分子經(jīng)皮/跨膜轉(zhuǎn)運(yùn)機(jī)理與促滲技術(shù)；
— 生物大分子經(jīng)皮經(jīng)粘膜轉(zhuǎn)運(yùn)的 in vitro 評(píng)價(jià)體系建立。
4、藥品、保健食品化妝品組方、工藝及質(zhì)量標(biāo)準(zhǔn)研究
Research Fields:
1. Functional Material and controlled/sustained delivery system:
— Design and Synthesis of Press Sensitive Adhesive for TTS;
— In Situ Gel Material ;
2. Computer Simulation and PK/PD Correlation of TTS
— Transdermal-CAD and Optimization Design
— Percutaneous Permeation Dynamics of Drugs;
3. Biomacromolecule Transdermal and Trans-Mucosa Delivery System
— Permeation Enhancement Technology and Mechanism;
— in vitro Evaluation Method for Transdermal and Trans-Mucosa System of
Biomacromolecule;
科研課題： RESEARCH PROJECT
近三年負(fù)責(zé)國家級(jí)科研項(xiàng)目
1、國家十一五重大新藥創(chuàng)制項(xiàng)目《中藥 TTS 給藥系統(tǒng)關(guān)鍵技術(shù)研究與評(píng)價(jià)》
（ 2009ZX09502-010） 項(xiàng)目組長(zhǎng)
2、國家十二五重大新藥創(chuàng)制項(xiàng)目《適用于中藥的新型輔料研究》
（ 2011ZX09501-001-02 ） 課題技術(shù)負(fù)責(zé)人，副組長(zhǎng) 新型系列兩親性熱熔壓敏膠
結(jié)構(gòu)設(shè)計(jì)與材料的性能評(píng)價(jià)。
3、國家十一五科技支撐計(jì)劃重點(diǎn)項(xiàng)目《止痛活血類中藥給藥關(guān)鍵技術(shù)及評(píng)價(jià)方法
研究》（ 2006BAI09B08-12） 課題負(fù)責(zé)人
4、國家自然科學(xué)基金《基于特異性促滲的芍甘非均相經(jīng)皮給藥系統(tǒng)設(shè)計(jì)及評(píng)價(jià)》
（ 30873448） 課題負(fù)責(zé)人
5、國家自然科學(xué)基金《基于 MEMS 技術(shù)的載藥聚合物微針 TTS 給藥系統(tǒng)研究》
（ 60976081） 合作單位負(fù)責(zé)人
National research projects
1. China Eleventh 5-years Plan —Great projects of major national drug, " Evaluation
of key technology for new traditional Chinese medicine transdermal delivery
system " Project leader
2. China Twelfth 5-year Plan—Great projects of major national drug, " Evaluation of
key technology for new traditional Chinese medicine transdermal delivery system "
Project technology leader
3. National Eleventh Five-Year key project of science and technology support
program, " Investigation of key technology and evaluation method for the Chinese
Traditional Drugs alleviate pain and promoting blood flow activity transdermal
delivery," sub-project leader
4. National Natural Science Foundation of China "based on specific penetration of
heterogeneous Shaogan transdermal delivery system design and evaluation" Project
leader
5. National Natural Science Foundation of China "based on polymer MEMS
drug-loaded microneedle transdermal drug delivery system " Cooperator
近三年論文、專利和特邀報(bào)告： PAPER、PATENT AND INVITED SPEECH ( last three years)
期刊論文
1． Xiao Tong, Qing Wang*, Hai-xia Wang, Xiao-Hui Li*, Wei Wu, Xin-yi Che Fabrication of pH Sensitive Amphiphilic Hot-Melt Pressure Sensitive Adhesives for Transdermal Drug Delivery System International Journal of Adhesion & Adhesives 48, p217-223, 2014 on line SCI IF：2.17
2． Xiao-Hui Li, Mei-Ling Huang, Shi-Miao Wang, Qing Wang* Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase Inhibitor on HDAC4 and K562 Leukemia Cell Asian Pacific Journal of Cancer Prevention, 14(9), 2013 SCI IF：1.27
3．Mingming Chang, Xiaohui Li,* Yuming Sun, Fang Cheng,Yueqing Li, Weijie Zhao and Qing Wang* A Potential Mechanism of a Cationic Cyclopeptide for Enhancing Insulin Delivery across Caco-2 Cell Monolayers Biol. Pharm. Bull. 36(10), p1602–1607, 2013 SCI IF:1.85
4．Yongnan Hu, Qing Wang* , Yuming Sun, Xiaohui Li* , Xinyi Che, Haihong Zhang Studies on In Vitro Release Performance of Hydrophilic Drugs and Lipophilic Drugs in Amphiphilic SIS-Based Hot-Melt Pressure Sensitive Adhesives Applied Mechanics and Materials Vols. 395-396 , p389-398, 2013 EI
5．Mingming Chang, Xiaohui Li, Yuming Sun, Fang Cheng, Qing Wang*, Xiaohuan Xie, Weijie Zhao, and Xin Tian, Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin, Molecular Pharmaceutics, 10(3) , p951-957, 2013 SCI IF:5.634
6．Zhong-fu Zhao, Bing Fang, Xiaohui Li, Qing Wang*, Development of hot-melt pressure sensitive adhesives for transdermal drug delivery, Journal of Adhesion Science and Technology, 27(2), p143-153, 2013 SCI IF:1.048
7．Qing Wang, Yong-zhao Wang, Zhong-fu Zhao*, Bing Fang, Synthesis of SIS-based hot-melt pressure sensitive adhesives for transdermal delivery of hydrophilic drugs, International Journal of Adhesion and Adhesives. 34, p62–67, 2012 SCI IF:2.345
8．J.J. Hao, Y.M. Sun, Qing Wang*, Xiao Tong, Hua Zhang, Qing Zhang, Effect and mechanism of penetration enhancement of organic base and alcohol on Glycyrrhetinic acid in vitro, International Journal of Pharmaceutics 399, p102–108, 2010 SCI IF:3.874
9．Li-li Hua, Yang Li, Qing Wang*, Yong-nan Hu, Zhong-fu Zhao*, Fabrication of amphiphilic hot-melt pressure sensitive adhesives for transdermal drug delivery, Journal of Adhesion Science and Technology , 26, 8-9, p1109-1122, 2012. SCI IF:1.048
10．Wang Q, Li ZJ, Sun L, Gao LY, Li MH, Hao JJ, Zhang X, Sun YM*., Pharmacokinetic study of lappaconitine hydrobromide in mice by LC-MS. Acta Pharmaceutica Sinica. 46 (4) , p432-437, 2011
11．姜博海，汪 晴，王世盛，蔡 蕊，趙偉杰* 應(yīng)用近紅外光譜法建立傷癤膏制備過程中黃芩苷的含量模型[J] 光譜學(xué)與光譜分析33 (01): 74-77 2013
12．孫玉明 楊洋 李冬 蒲婷婷 謝曉環(huán) 汪晴* 芍藥苷對(duì)甘草酸及甘草次酸大鼠體內(nèi)藥代動(dòng)力學(xué)的影響[J] 中國藥學(xué)學(xué)報(bào) 47,8, 599-603, 2012.
13．張欣, 孫玉明, 汪晴*, 趙忠夫, 胡勇男, DOP對(duì)SIS型熱熔壓敏膠軟化溫度及體外釋藥性能的影響[J]. 中國醫(yī)藥工業(yè)雜志,（ 41） 11 p37-41, 2010.
14．常明明, 孫玉明, 汪晴*, 錢勇, 張欣, 王天富 止痛活血壓敏膠貼片中有效成分的體外釋放研究[J] 中成藥 32（1） p43-47, 2010
15．孟昱 汪晴 蔡蕊 李梅 孟慶剛 趙偉杰 保健品中枸櫞酸西地那非成分近紅外快速定性定量分析[J]. 大連理工大學(xué)報(bào) ,2010, 06:867 -870.
16. Studies in Fabrication of Amphiphilic Hot-Melt Pressure Sensitive Adhesives and Applicability for Transdermal Drug Delivery EXCIPIENTFEST ASIA Beijing 2012.11
專利：
1. 汪晴 等.控釋軟膏組合基質(zhì)及其制備方法,2010.8.25,中國, ZL2007 1 0011196.4
2. 汪晴 等.兩親性熱熔壓敏膠及其制備方法,2012.7.25,中國, ZL2010 1 0242108.3
3. 汪晴 等.用于促進(jìn)甘草次酸經(jīng)皮滲透組合物,2012.1.4,中國, ZL2010 1 0242109.
4. 汪晴 等.一種含有芍藥苷和甘草次酸制劑及其制備方法,2012.5.30,中國,
ZL2011 1 0184048.9
5. 汪晴 等.一種格拉司瓊和其鹽酸鹽制劑,2013.2.6,中國, ZL2008 1 0228371.X
6. 汪晴等 一種具有鎮(zhèn)痛抗炎作用的苯甲酰基烏頭原堿凝膠劑 ZL200910220428.6
7. 汪晴等 一組具有促進(jìn)經(jīng)皮和跨膜滲透作用的多肽及其應(yīng)用 ZL201310052658.2
國際會(huì)議:
1. Studies in Fabrication of Amphiphilic Hot-Melt PSA dhesives andApplicability for Transdermal Drug Delivery EXCIPIENTFEST ASIA Beijing 2012.11
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